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Article

Minimal and extended hammerheads utilize a similar dynamic reaction mechanism for catalysis.

RNA (New York, N.Y.) - 1 Jan 2008

Nelson Jennifer A, Uhlenbeck Olke C

Abstract excerpt

Analysis of the catalytic activity of identical mutations in the catalytic cores of nHH8, a very active "extended" hammerhead, and HH16, a less active "minimal" hammerhead, reveal that the tertiary Watson-Crick base pair between C3 and G8 seen in the recent structure of the Schistosoma mansoni extended hammerhead can be replaced by other base pairs in both backgrounds. This supports the model that both...

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Identifiers

PMID: 17998291
DOI: 10.1261/rna.717908
PMCID: PMC2151028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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