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Article

Functional evolution of the vitamin D and pregnane X receptors

12 Nov 2007

Abstract excerpt

BACKGROUND: The vitamin D receptor (VDR) and pregnane X receptor (PXR) are nuclear hormone receptors of the NR1I subfamily that show contrasting patterns of cross-species variation. VDR and PXR are thought to have arisen from duplication of an ancestral gene, evident now as a single gene in the genome of the chordate invertebrate Ciona intestinalis (sea squirt). VDR genes have been detected in a wide range of...

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PMID: 17997857
DOI: 10.1186/1471-2148-7-222

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