Article
Screening of Iranian thalassemic families for the most common deletions of the beta-globin gene cluster.
Hemoglobin - 1 Jan 2007
Esteghamat Fatemehsadat, Imanian Hashem, Azarkeivan Azita, Pourfarzad Farzin, Almadani Navid, Najmabadi Hossein
Abstract excerpt
Deltabeta-thalassemia (thal) is a disorder, characterized by increased levels of fetal hemoglobin (Hb F) in adult life. A considerable number of deletions of variable size and position in the beta-globin gene cluster are associated with the clinical manifestation of deltabeta-thal. In this study we have determined the presence of the eight most common deletions in Iranian patients. Thirty-two patients from 19...
Topics
- Adolescent
- Adult
- Child, Preschool
- Cohort Studies
- DNA Mutational Analysis
- Family
- Female
- Fetal Hemoglobin
- Genetic Testing
- Genotype
- Globins
- Hemoglobins, Abnormal
- Humans
- Iran
- Male
- Middle Aged
- Multigene Family
- Mutation