Article
Sistani population: a different spectrum of β-thalassemia mutations from other ethnic groups of Iran.
Hemoglobin - 1 Jan 2013
Miri-Moghaddam Ebrahim, Zadeh-Vakili Azita, Nikravesh Abbas, Sistani Shohreh Sanei, Naroie-Nejad Mehrnaz
Abstract excerpt
This study aimed to characterize the molecular spectrum of β-thalassemia (β-thal) mutations and evaluate the services available for prenatal diagnosis (PND) among the Sistani population of Iran. Mutations were analyzed with amplification refractory mutation system (ARMS), gap-polymerase chain reaction (gap-PCR), multiplex ligation-dependent probe amplification (MLPA) analysis and direct sequencing. Fetal...
Topics
- Adolescent
- Adult
- Alleles
- Child
- Codon
- Consanguinity
- DNA Mutational Analysis
- Ethnicity
- Female
- Fetal Diseases
- Gene Frequency
- Humans
- Introns
- Iran
- Male
- Multiplex Polymerase Chain Reaction
- Mutation
- Polymerase Chain Reaction