Article
Genetic research and clinical analysis of β-globin gene cluster deletions in the Chinese population of Fujian province: A 14-year single-center experience.
Journal of clinical laboratory analysis - 1 Feb 2022
Chen Meihuan, Zhang Min, Chen Lingji, Lin Na, Wang Yan, Xu Liangpu, Huang Hailong
Abstract excerpt
BACKGROUND: Heterozygotes of HPFH and δβ thalassemia are clinically asymptomatic or have mild hemoglobin (Hb) values. However, when both HPFH and δβ-thalassemia are coinherited with heterozygous β-thalassemia, patients may progress to a clinical phenotype of thalassemia intermedia or thalassemia major. The purpose of this study was to characterize the genotypes and analyze the phenotypes of these disorders in...
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