Article
A comprehensive molecular characterization of beta thalassemia in a highly heterogeneous population.
Blood cells, molecules & diseases - 15 Jun 2011
Akhavan-Niaki Haleh, Derakhshandeh-Peykar Poupak, Banihashemi Ali, Mostafazadeh Amrollah, Asghari Beheshteh, Ahmadifard Mohammad-Reza, Azizi Mandana, Youssefi Ali, Elmi Maryam Mitra
Abstract excerpt
In Iran, the prevalence of beta-thalassemia trait is approximately 4-8% in most areas, and in Mazandaran province 10% of the population are carriers. Twenty four beta-globin gene mutations were identified in 1635 persons with beta-thalassemia trait using reverse dot blot and restriction fragment length polymorphism analysis. The predominant mutations included IVSII-1 (G-A) (61%), codon 30 (G-C) (7.5%), codon 22...
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