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Article

No evidence that established type 2 diabetes susceptibility variants in the PPARG and KCNJ11 genes have pleiotropic effects on early growth.

Diabetologia - 1 Jan 2008

Bennett A J, Sovio U, Ruokonen A, Martikainen H, Pouta A, Hartikainen A-L, Franks S, Elliott P, Järvelin M-R, McCarthy M I

Abstract excerpt

AIMS/HYPOTHESIS: The P12A variant in the PPARG gene and the E23K polymorphism in KCNJ11 are both known to influence individual predisposition to type 2 diabetes. If the effect of these variants on insulin secretion and action were to extend to an influence on early growth (which is largely mediated by insulin), it would offer an explanation for observed associations between low birthweight and subsequent...

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Source

Identifiers

PMID: 17994213
DOI: 10.1007/s00125-007-0863-1

Genes

KCNJ11
PPARG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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No evidence that established type 2 diabetes susceptibility variants in the PPARG and KCNJ11 genes have pleiotropic effects on early growth.PMID 17994213Read ↗

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