Article
Detailed analysis of variation at and around mitochondrial position 16189 in a large Finnish cohort reveals no significant associations with early growth or metabolic phenotypes at age 31 years.
The Journal of clinical endocrinology and metabolism - 1 Aug 2007
Das Sreena, Bennett Amanda J, Sovio Ulla, Ruokonen Aimo, Martikainen Hannu, Pouta Anneli, Hartikainen Anna-Liisa, Franks Stephen, Elliott Paul, Poulton Joanna, Järvelin Marjo-Riitta, McCarthy Mark I
Abstract excerpt
CONTEXT: Mitochondrial dysfunction is increasingly implicated in pathogenesis of adult metabolic disease. Rare mitochondrial (mt) DNA mutations impair glucose homeostasis, but the contribution of common variants is unclear. In small studies, variation within the OriB origin of replication (at mt1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.