Article
Genetic variation in transforming growth factor-beta1 gene associated with increased risk of esophageal squamous cell carcinoma.
Tissue antigens - 1 Dec 2007
Wei Y-S, Xu Q-Q, Wang C-F, Pan Y, Liang F, Long X-K
Abstract excerpt
The genetic alterations leading to esophageal squamous cell carcinoma (ESCC) are gradually being discovered. A wide variety of genes have been associated with ESCC development as well as tumor progression. Transforming growth factor-beta1 (TGF-beta1) is a multifunctional cytokine; it promotes tumor growth and metastasis in later stages of of cancer development. Variations in the DNA sequence in the TGF-beta1 gene...
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