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Article

Impact of TGF-β1 -509C/T and 869T/C polymorphisms on glioma risk and patient prognosis.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Aug 2015

Vieira de Castro Joana, Gonçalves Céline S, Costa Sandra, Linhares Paulo, Vaz Rui, Nabiço Ricardo, Amorim Júlia, Viana-Pereira Marta, Reis Rui M, Costa Bruno M

Abstract excerpt

Transforming growth factor beta (TGF-β) plays an important role in carcinogenesis. Two polymorphisms in the TGF-β1 gene (-509C/T and 869T/C) were described to influence susceptibility to gastric and breast cancers. The 869T/C polymorphism was also associated with overall survival in breast cancer patients. In the present study, we investigated the relevance of these TGF-β1 polymorphism in glioma risk and...

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PMID: 25813152
DOI: 10.1007/s13277-015-3343-0

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