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Article

Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos.

Cardiovascular research - 1 Nov 2008

Zhao Long, Zhao Xinyi, Tian Tian, Lu Quanlong, Skrbo-Larssen Nirma, Wu Di, Kuang Zheng, Zheng Xiaofeng, Han Yanchao, Yang Shuyan, Zhang Chuanmao, Meng Anming

Abstract excerpt

AIMS: Tropomyosin (Tpm) proteins, encoded by four Tpm genes (Tpm1-4), are associated with the stabilization of the F-actin filaments and play important roles in modulating muscle contraction. So far, little is known about Tpm4 function in embryonic heart development and its involvement in the cardiovascular diseases. In this study, we investigated functions of different isoforms of tpm4 in embryonic heartbeat in...

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PMID: 18583338
DOI: 10.1093/cvr/cvn177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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