Article
Variation in iron homeostasis genes between patients with ARDS and healthy control subjects.
Chest - 1 Jun 2008
Lagan Anna L, Quinlan Gregory J, Mumby Sharon, Melley Daniel D, Goldstraw Peter, Bellingan Geoff J, Hill Michael R, Briggs David, Pantelidis Panagiotis, du Bois Roland M, Welsh Kenneth I, Evans Timothy W
Abstract excerpt
BACKGROUND: Abnormal plasma and lung iron mobilization is associated with the onset and progression of ARDS and is detectable in specific at-risk populations. Patients with ARDS also have pronounced oxidative and nitrosative stress that can be catalyzed and thereby aggravated by the bioavailability of redox active iron. ARDS of pulmonary and extrapulmonary origin may differ pathophysiologically and require...
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