Article
Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome.
American journal of respiratory and critical care medicine - 1 Sept 2002
Marshall Richard P, Webb Suzanne, Bellingan Geoffrey J, Montgomery Hugh E, Chaudhari Babar, McAnulty Robin J, Humphries Steve E, Hill Mike R, Laurent Geoffrey J
Abstract excerpt
Acute respiratory distress syndrome (ARDS) is an often fatal condition for which a genetic predisposition is postulated, although no specific genes have been identified to date. Angiotensin converting enzyme (ACE) has a potential role in the pathogenesis of ARDS via effects on pulmonary vascular tone/permeability, epithelial cell survival, and fibroblast activation. Forty-seven percent of the variance in plasma...
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