Article
HFE gene variants and iron-induced oxygen radical generation in idiopathic pulmonary fibrosis.
The European respiratory journal - 1 Feb 2015
Sangiuolo Federica, Puxeddu Ermanno, Pezzuto Gabriella, Cavalli Francesco, Longo Giuliana, Comandini Alessia, Di Pierro Donato, Pallante Marco, Sergiacomi Gianluigi, Simonetti Giovanni, Zompatori Maurizio, Orlandi Augusto, Magrini Andrea, Amicosante Massimo, Mariani Francesca, Losi Monica, Fraboni Daniela, Bisetti Alberto, Saltini Cesare
Abstract excerpt
In idiopathic pulmonary fibrosis (IPF), lung accumulation of excessive extracellular iron and macrophage haemosiderin may suggest disordered iron homeostasis leading to recurring microscopic injury and fibrosing damage. The current study population comprised 89 consistent IPF patients and 107 controls. 54 patients and 11 controls underwent bronchoalveolar lavage (BAL). Haemosiderin was assessed by Perls' stain,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.