Article
A sucrose-rich diet induces mutations in the rat colon.
Cancer research - 1 Aug 2002
Dragsted Lars O, Daneshvar Bahram, Vogel Ulla, Autrup Herman N, Wallin Håkan, Risom Lotte, Møller Peter, Mølck Anne M, Hansen Max, Poulsen Henrik E, Loft Steffen
Abstract excerpt
A sucrose-rich diet has repeatedly been observed to have cocarcinogenic actions in the colon and liver of rats and to increase the number of aberrant crypt foci in rat colon. To investigate whether sucrose-rich diets might directly increase the genotoxic response in the rat colon or liver, we have added sucrose to the diet of Big Blue rats, a strain of Fischer rats carrying 40 copies of the lambda-phage on...
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