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Article

Deconstruction of vulnerability to complex diseases: enhanced effect sizes and power of intermediate phenotypes.

TheScientificWorldJournal - 2 Nov 2007

Goldman David, Ducci Francesca

Abstract excerpt

The deconstruction of vulnerability to complex disease with the help of intermediate phenotypes, including the heritable and disease-associated endophenotypes, is a legacy of Henri Begleiter. Systematic searches for genes influencing complex disorders, including bipolar disorder, have recently been completed using whole genome association (WGA), identifying a series of validated loci. Using this information, it...

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Identifiers

PMID: 17982585
DOI: 10.1100/tsw.2007.210
PMCID: PMC5901150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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