Article
Common and rare variant analysis in early-onset bipolar disorder vulnerability.
PloS one - 1 Jan 2014
Jamain Stéphane, Cichon Sven, Etain Bruno, Mühleisen Thomas W, Georgi Alexander, Zidane Nora, Chevallier Lucie, Deshommes Jasmine, Nicolas Aude, Henrion Annabelle, Degenhardt Franziska, Mattheisen Manuel, Priebe Lutz, Mathieu Flavie, Kahn Jean-Pierre, Henry Chantal, Boland Anne, Zelenika Diana, Gut Ivo, Heath Simon, Lathrop Mark, Maier Wolfgang, Albus Margot, Rietschel Marcella, Schulze Thomas G, McMahon Francis J, Kelsoe John R, Hamshere Marian, Craddock Nicholas, Nöthen Markus M, Bellivier Frank, Leboyer Marion
Abstract excerpt
Bipolar disorder is one of the most common and devastating psychiatric disorders whose mechanisms remain largely unknown. Despite a strong genetic contribution demonstrated by twin and adoption studies, a polygenic background influences this multifactorial and heterogeneous psychiatric disorder. To identify susceptibility genes on a severe and more familial sub-form of the disease, we conducted a genome-wide...
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