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Article

Impact of ozone exposure on the phagocytic activity of human surfactant protein A (SP-A) and SP-A variants.

American journal of physiology. Lung cellular and molecular physiology - 1 Jan 2008

Mikerov Anatoly N, Umstead Todd M, Gan Xiaozhuang, Huang Weixiong, Guo Xiaoxuan, Wang Guirong, Phelps David S, Floros Joanna

Abstract excerpt

Surfactant protein A (SP-A) enhances phagocytosis of Pseudomonas aeruginosa. SP-A1 and SP-A2 encode human (h) SP-A; SP-A2 products enhance phagocytosis more than SP-A1. Oxidation can affect SP-A function. We hypothesized that in vivo and in vitro ozone-induced oxidation of SP-A (as assessed by its carbonylation level) negatively affects its function in phagocytosis (as assessed by bacteria cell association). To...

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Identifiers

PMID: 17981957
DOI: 10.1152/ajplung.00288.2007
PMCID: PMC2964667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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