Article
Role of NOD2/CARD15 in coronary heart disease.
BMC genetics - 2 Nov 2007
El Mokhtari Nour Eddine, Ott Stephan J, Nebel Almut, Schäfer Arne, Rosenstiel Philip, Förster Matti, Nothnagel Michael, Simon Rüdiger, Schreiber Stefan
Abstract excerpt
BACKGROUND: Bacterial DNA has been repeatedly detected in atheromatous lesions of coronary heart disease (CHD) patients. Phylogenetic signatures in the atheroma lesions that are similar to those of bacterial biofilms on human barrier organs, including the respiratory or gastrointestinal tract, raise the question of a defective barrier function in CHD. NOD2 plays a major role in defense against bacterial invasion....
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