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Article

Predictive factors of oxaliplatin neurotoxicity: the involvement of the oxalate outcome pathway.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2007

Gamelin Laurence, Capitain Olivier, Morel Alain, Dumont Agnes, Traore Sory, Anne Le Bouil, Gilles Simard, Boisdron-Celle Michele, Gamelin Erick

Abstract excerpt

PURPOSE: Oxaliplatin displays a frequent dose-limiting neurotoxicity due to its interference with neuron voltage-gated sodium channels through one of its metabolites, oxalate, a calcium chelator. Different clinical approaches failed in neurotoxicity prevention, except calcium-magnesium infusions. We characterized oxalate outcome following oxaliplatin administration and its interference with cations and amino...

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Source

Identifiers

PMID: 17975148
DOI: 10.1158/1078-0432.CCR-07-0660

Genes

AGXT
ABCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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