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Article

SNPs in transporter and metabolizing genes as predictive markers for oxaliplatin treatment in colorectal cancer patients.

International journal of cancer - 15 Jun 2016

Kap Elisabeth J, Seibold Petra, Scherer Dominique, Habermann Nina, Balavarca Yesilda, Jansen Lina, Zucknick Manuela, Becker Natalia, Hoffmeister Michael, Ulrich Alexis, Benner Axel, Ulrich Cornelia M, Burwinkel Barbara, Brenner Hermann, Chang-Claude Jenny

Abstract excerpt

Oxaliplatin is frequently used as part of a chemotherapeutic regimen with 5-fluorouracil in the treatment of colorectal cancer (CRC). The cellular availability of oxaliplatin is dependent on metabolic and transporter enzymes. Variants in genes encoding these enzymes may cause variation in response to oxaliplatin and could be potential predictive markers. Therefore, we used a two-step procedure to comprehensively...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26835885
DOI: 10.1002/ijc.30026

Genes

ABCA9
ABCB11
ABCC10
GRHPR
GSTM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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