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Article

Genetic variants in DNA repair genes as potential predictive markers for oxaliplatin chemotherapy in colorectal cancer.

The pharmacogenomics journal - 1 Dec 2015

Kap E J, Seibold P, Richter S, Scherer D, Habermann N, Balavarca Y, Jansen L, Becker N, Pfütze K, Popanda O, Hoffmeister M, Ulrich A, Benner A, Ulrich C M, Burwinkel B, Brenner H, Chang-Claude J

Abstract excerpt

Oxaliplatin-based chemotherapy exerts its effects through generating DNA damage. Hence, genetic variants in DNA repair pathways could modulate treatment response. We used a prospective cohort of 623 colorectal cancer patients with stage II-IV disease treated with adjuvant/palliative chemotherapy to comprehensively investigate 1727 genetic variants in the DNA repair pathways as potential predictive markers for...

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Identifiers

PMID: 25778469
DOI: 10.1038/tpj.2015.8
PMCID: PMC4573779

Genes

MNAT1
XPC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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