Article
Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2008
Shiffman Dov, O'Meara Ellen S, Bare Lance A, Rowland Charles M, Louie Judy Z, Arellano Andre R, Lumley Thomas, Rice Kenneth, Iakoubova Olga, Luke May M, Young Bradford A, Malloy Mary J, Kane John P, Ellis Stephen G, Tracy Russell P, Devlin James J, Psaty Bruce M
Abstract excerpt
OBJECTIVE: We asked whether single nucleotide polymorphisms (SNPs) that had been nominally associated with cardiovascular disease in antecedent studies were also associated with cardiovascular disease in a population-based prospective study of 4522 individuals aged 65 or older. METHODS AND RESULTS: Based on antecedent studies, we prespecified a risk allele and an inheritance model for each of 74 SNPs. We then...
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