Article
Effects of 1 GeV/nucleon ⁵⁶Fe particles on longevity, carcinogenesis and neuromotor ability in Atm-deficient mice.
Radiation research - 1 Feb 2011
Yamamoto Mitsuko L, Hafer Kurt, Reliene Ramune, Fleming Sheila, Kelly Owen, Hacke Katrin, Schiestl Robert H
Abstract excerpt
As therapeutic uses of high-LET radiation become more prevalent and human space exploration continues to be a focus of NASA, it is important to understand the biological effects of high-LET radiation and the role of genetics in sensitivity to high-LET radiation. To study genetic susceptibility to radiation, we used mice deficient in Atm activity (AtmΔSRI). ATM is important in DNA repair, apoptosis and cell cycle...
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