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Article

Metabolism of tacrolimus (FK506) and recent topics in clinical pharmacokinetics.

Drug metabolism and pharmacokinetics - 1 Oct 2007

Iwasaki Kazuhide

Abstract excerpt

Tacrolimus (FK506), an immunosuppressive drug, is co-medicated with multiple drugs under clinical conditions. Tacrolimus is highly lipophilic and is excreted from the body after receiving extensive metabolism. Due to its narrow therapeutic window following organ transplantation, tacrolimus requires therapeutic drug monitoring by an enzyme immunoassay using the monoclonal antibody raised against tacrolimus....

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Identifiers

PMID: 17965516
DOI: 10.2133/dmpk.22.328

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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