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Article

Increased Exposure of Tacrolimus by Co-administered Mycophenolate Mofetil: Population Pharmacokinetic Analysis in Healthy Volunteers.

Scientific reports - 26 Jan 2018

Kim Jae Hyun, Han Nayoung, Kim Myeong Gyu, Yun Hwi-Yeol, Lee Sunhwa, Bae Eunjin, Kim Yon Su, Kim In-Wha, Oh Jung Mi

Abstract excerpt

The objective of the study was to investigate the pharmacokinetic drug-drug interactions between tacrolimus (TAC) and mycophenolate mofetil (MMF) in healthy Korean male volunteers. Seventeen volunteers participated in a three-period, single-dose, and fixed sequence study. They sequentially received MMF, TAC, and the combination. Concentrations of TAC, mycophenolic acid (MPA), and its metabolites MPA...

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Identifiers

PMID: 29374217
DOI: 10.1038/s41598-018-20071-3
PMCID: PMC5786104

Genes

ABCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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