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Article

Role of DNA mismatch repair and double-strand break repair in genome stability and antifungal drug resistance in Candida albicans.

Eukaryotic cell - 1 Dec 2007

Legrand Melanie, Chan Christine L, Jauert Peter A, Kirkpatrick David T

Abstract excerpt

Drug resistance has become a major problem in the treatment of Candida albicans infections. Genome changes, such as aneuploidy, translocations, loss of heterozygosity, or point mutations, are often observed in clinical isolates that have become resistant to antifungal drugs. To determine whether these types of alterations result when DNA repair pathways are eliminated, we constructed yeast strains bearing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17965250
DOI: 10.1128/EC.00299-07
PMCID: PMC2168241

Genes

MRE11
MSH2
PMS1
RAD50
RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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