Genetic polymorphisms of CYP2E1 and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study.

doi:10.1158/1055-9965.EPI-08-0698

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Article

Genetic polymorphisms of CYP2E1 and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2009

Morita Makiko, Le Marchand Loïc, Kono Suminori, Yin Guang, Toyomura Kengo, Nagano Jun, Mizoue Tetsuya, Mibu Ryuichi, Tanaka Masao, Kakeji Yoshihiro, Maehara Yoshihiko, Okamura Takeshi, Ikejiri Koji, Futami Kitaroh, Maekawa Takafumi, Yasunami Yohichi, Takenaka Kenji, Ichimiya Hitoshi, Imaizumi Nobutoshi

Abstract excerpt

Cytochrome P450 2E1 (CYP2E1) is involved in the metabolic activation of a wide variety of potential carcinogens, and functional polymorphisms in the CYP2E1 gene have been investigated in relation to colorectal cancer. We examined the relation of the CYP2E1 RsaI and 96-bp insertion polymorphisms to colorectal cancer risk and the interaction between these polymorphisms and some lifestyle risk factors. Subjects were...

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PMID: 19124503
DOI: 10.1158/1055-9965.EPI-08-0698

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