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Article

Role of CYP2E1 genotypes in susceptibility to colorectal cancer in the Kashmiri population.

Human genomics - 1 Oct 2011

Sameer A Syed, Nissar Saniya, Qadri Qurteeba, Alam Shafia, Baba Shahid Mudasir, Siddiqi Mushtaq A

Abstract excerpt

Cytochrome P450 2E1 (CYP2E1) is a key enzyme involved in the metabolic activation of procarcinogens such as N-nitrosoamines and low-molecular-weight organic compounds. The main aim of this study was to determine whether CYP450 2E1 polymorphisms are associated with the risk of colorectal cancer (CRC). We investigated the genotype distribution of the CYP2E1 gene RsaI and a 96-base pair (bp) insertion in 86 CRC...

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Identifiers

PMID: 22155602
DOI: 10.1186/1479-7364-5-6-530
PMCID: PMC3525247

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