Article
Interaction between cytochrome P-450 2E1 polymorphisms and environmental factors with risk of esophageal and stomach cancers in Chinese.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2002
Gao Changming, Takezaki Toshiro, Wu Jianzhong, Li Zhongyou, Wang Jiandong, Ding Jianhua, Liu Yanting, Hu Xu, Xu Tianliang, Tajima Kazuo, Sugimura Haruhiko
Abstract excerpt
Because cytochrome P-450 2E1 (CYP2E1) is involved in metabolic activation of environmental chemical carcinogens, gene polymorphisms that alter its functions may be associated with cancer susceptibility. However, previous studies have revealed disconcordant results with regard to cancer risk. To investigate gene-environment interactions with the RsaI polymorphism of CYP2E1 in terms of risk of esophageal and...
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