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CYP2E1 Rsa I/Pst I polymorphism and esophageal cancer risk: a meta-analysis based on 1,088 cases and 2,238 controls.

Medical oncology (Northwood, London, England) - 1 Mar 2011

Niu Yuming, Yuan Hua, Leng Weidong, Pang Yongchu, Gu Ning, Chen Ning

Abstract excerpt

The common functional CYP2E1 Rsa I/Pst I polymorphism may influence the risk of esophageal cancer. However, the published results are conflicting. We therefore conducted a meta-analysis comprised of 11 published case-control studies with 1,088 cases and 2,238 controls. Odds ratios (ORs) with 95% confidence interval (CIs) were used to assess the strength of the association. Overall, the pooled ORs were 0.53 (95%...

Topics

Case-Control Studies
Cytochrome P-450 CYP2E1
Esophageal Neoplasms
Ethnicity
Genetic Predisposition to Disease
Genotype
Humans
Polymorphism, Genetic
Prognosis
Risk Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20195803
DOI: 10.1007/s12032-010-9455-x

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