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Article

Genetic polymorphisms in the apoptosis-associated genes FAS and FASL and breast cancer risk.

Carcinogenesis - 1 Dec 2007

Crew Katherine D, Gammon Marilie D, Terry Mary Beth, Zhang Fang Fang, Agrawal Meenakshi, Eng Sybil M, Sagiv Sharon K, Teitelbaum Susan L, Neugut Alfred I, Santella Regina M

Abstract excerpt

FAS and FAS ligand (FASL) play key roles in apoptotic signaling and down-regulation of this pathway may facilitate tumorigenesis. Alterations in apoptosis genes may affect cancer risk by influencing individual susceptibility to environmental carcinogens. Using a population-based breast cancer case-control study on Long Island, New York, we examined whether polymorphisms in FAS and FASL modified the association...

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Source

Identifiers

PMID: 17962219
DOI: 10.1093/carcin/bgm211

Genes

FAS
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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