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Article

Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron.

Journal of cell science - 15 Dec 2014

Nguyen Phuong Anh T, Liou Willisa, Hall David H, Leroux Michel R

Abstract excerpt

How signaling domains form is an important, yet largely unexplored question. Here, we show that ciliary proteins help establish two contiguous, yet distinct cyclic GMP (cGMP) signaling compartments in Caenorhabditis elegans thermosensory AFD neurons. One compartment, a bona fide cilium, is delineated by proteins associated with Bardet-Biedl syndrome (BBS), Meckel syndrome and nephronophthisis at its base, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25335890
DOI: 10.1242/jcs.157610
PMCID: PMC4265742

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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