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Article

Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia.

Proceedings of the National Academy of Sciences of the United States of America - 18 Mar 2008

Berbari Nicolas F, Lewis Jacqueline S, Bishop Georgia A, Askwith Candice C, Mykytyn Kirk

Abstract excerpt

Primary cilia are ubiquitous cellular appendages that provide important yet not well understood sensory and signaling functions. Ciliary dysfunction underlies numerous human genetic disorders. However, the precise defects in cilia function and the basis of disease pathophysiology remain unclear. Here, we report that the proteins disrupted in the human ciliary disorder Bardet-Biedl syndrome (BBS) are required for...

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Identifiers

PMID: 18334641
DOI: 10.1073/pnas.0711027105
PMCID: PMC2393805

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