Disrupting the male germ line to find infertility and contraception targets.

doi:10.1016/j.ando.2014.04.006

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Article

Disrupting the male germ line to find infertility and contraception targets.

Annales d'endocrinologie - 1 May 2014

Archambeault Denise R, Matzuk Martin M

Abstract excerpt

Genetically-manipulated mouse models have become indispensible for broadening our understanding of genes and pathways related to male germ cell development. Until suitable in vitro systems for studying spermatogenesis are perfected, in vivo models will remain the gold standard for inquiry into testicular function. Here, we discuss exciting advances that are allowing researchers faster, easier, and more...

Topics

Animals
Antispermatogenic Agents
CRISPR-Cas Systems
Disease Models, Animal
Fertility
Gene Knockout Techniques
Genes, Reporter
Genomic Library
Humans
Male
Mice
Mice, Knockout
Mutagenesis
Phenotype
Spermatogenesis
Spermatozoa

Source

Open in PubMed

Identifiers

PMID: 24793995
DOI: 10.1016/j.ando.2014.04.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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