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Characterization of cancer stem cells in chronic myeloid leukaemia

25 Oct 2007

Abstract excerpt

CML (chronic myeloid leukaemia) is a myeloproliferative disease that originates in an HSC (haemopoietic stem cell) as a result of the t(9;22) translocation, giving rise to the Ph (Philadelphia chromosome) and bcr-abl oncoprotein. The disease starts in CP (chronic phase), but as a result of genomic instability, it progresses over time to accelerated phase and then to BC (blast crisis), becoming increasingly...

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PMID: 17956348
DOI: 10.1042/bst0351347

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