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Article

Kir6.2 mutations causing neonatal diabetes prevent endocytosis of ATP-sensitive potassium channels.

The EMBO journal - 6 Sept 2006

Mankouri Jamel, Taneja Tarvinder K, Smith Andrew J, Ponnambalam Sreenivasan, Sivaprasadarao Asipu

Abstract excerpt

ATP-sensitive potassium (KATP) channels couple the metabolic status of a cell to its membrane potential-a property that endows pancreatic beta-cells with the ability to regulate insulin secretion in accordance with changes in blood glucose. The channel comprises four subunits each of Kir6.2 and the sulphonylurea receptor (SUR1). Here, we report that KATP channels undergo rapid internalisation from the plasma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Potassium Channels, Inwardly Rectifying

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Source

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Identifiers

PMID: 16902404
DOI: 10.1038/sj.emboj.7601275
PMCID: PMC1560363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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