Congenital Hyperinsulinism–Associated <i>ABCC8</i> Mutations That Cause Defective Trafficking of ATP-Sensitive K+ Channels

Abstract excerpt

Congenital hyperinsulinism (CHI) is a disease characterized by persistent insulin secretion despite severe hypoglycemia. Mutations in the pancreatic ATP-sensitive K(+) (K(ATP)) channel proteins sulfonylurea receptor 1 (SUR1) and Kir6.2, encoded by ABCC8 and KCNJ11, respectively, is the most common cause of the disease. Many mutations in SUR1 render the channel unable to traffic to the cell surface, thereby...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cardiac Ischemia and Reperfusion
• Share to Hyperglycemia and glycemic control in critically ill and hospitalized patients
• Share to Neonatal Respiratory Health Research