Article
Genomewide linkage analysis of the granulomatous mitsuda reaction implicates chromosomal regions 2q35 and 17q21.
The Journal of infectious diseases - 15 Oct 2007
Ranque Brigitte, Alter Andrea, Mira Marcelo, Thuc Nguyen Van, Thai Vu Hong, Huong Nguyen Thu, Ba Nguyen Ngoc, Khoa Pham Xuan, Schurr Erwin, Abel Laurent, Alcaïs Alexandre
Abstract excerpt
The Mitsuda reaction, a delayed granulomatous skin reaction elicited by the intradermal injection of heat-killed Mycobacterium leprae, is an in vivo test reflecting the ability to generate an immune granuloma after sensitization by diverse mycobacterial infections. Accumulating evidence for the genetic control of the Mitsuda reaction has been reported. We performed a genomewide linkage scan for the quantitative...
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