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Article

A recessive major gene controls the mitsuda reaction in a region endemic for leprosy.

The Journal of infectious diseases - 15 Oct 2005

Ranque Brigitte, Alcais Alexandre, Thuc Nguyen Van, Woynard Sebastien, Thai Vu Hong, Huong Nguyen Thu, Ba Nguyen Ngoc, Khoa Pham Xuan, Schurr Erwin, Abel Laurent

Abstract excerpt

BACKGROUND: Leprosy is a chronic infectious disease caused by Mycobacterium leprae. The Mitsuda reaction is a delayed granulomatous skin reaction elicited by intradermal injection of heat-killed M. leprae. Interestingly, results of the Mitsuda test are positive in the majority of individuals, even in areas not endemic for M. leprae. Like leprosy, the Mitsuda reaction is thought to be genetically controlled, but...

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PMID: 16170767
DOI: 10.1086/466535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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A recessive major gene controls the mitsuda reaction in a region endemic for leprosy.PMID 16170767Read ↗

Granulomatous reaction to intradermal injection of lepromin (Mitsuda reaction) is linked to the human NRAMP1 gene in Vietnamese leprosy sibships.Semantic proximity Read ↗

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Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population.Semantic proximity Read ↗

Susceptibility to leprosy is linked to the human NRAMP1 gene.Semantic proximity Read ↗

Is there an answer? Is there a genetic basis for human susceptibility to leprosy?Semantic proximity Read ↗

A major gene controls leprosy susceptibility in a hyperendemic isolated population from north of Brazil.Semantic proximity Read ↗

Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy.Semantic proximity Read ↗

No evidence of linkage between Mitsuda reaction and the NRAMP1 locus.Semantic proximity Read ↗

Complex segregation analysis of leprosy in southern Vietnam.Semantic proximity Read ↗

CUBN and NEBL common variants in the chromosome 10p13 linkage region are associated with multibacillary leprosy in Vietnam.Semantic proximity Read ↗

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