Article
Epigenetics: molecular mechanisms and implications for disease.
Trends in molecular medicine - 1 Jan 2010
Handel Adam E, Ebers George C, Ramagopalan Sreeram V
Abstract excerpt
Epigenetics is rising to prominence in biology as a mechanism by which environmental factors have intermediate-term effects on gene expression without changing the underlying genetic sequence. This can occur through the selective methylation of DNA bases and modification of histones. There are wide-ranging implications for the gene-environment debate and epigenetic mechanisms are causing a reevaluation of many...
Topics
- Animals
- DNA Methylation
- Disease
- Epigenesis, Genetic
- Evolution, Molecular
- Genetic Predisposition to Disease
- Genetics, Medical
- Histones
- Humans