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Article

Arsenic exposure is associated with DNA hypermethylation of the tumor suppressor gene p16

1 Dec 2014

Abstract excerpt

BACKGROUND: Occupational and environmental exposure to inorganic arsenic leads to development of cancer and represents a significant health hazard in more than 70 countries. The underlying mechanism for arsenic-induced carcinogenesis remains unclear. Laboratory studies suggest that arsenic is a poor mutagen but may cause epigenetic silencing of key tumor suppressor genes such as p16 through DNA hypermethylation....

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PMID: 25598836
DOI: 10.1186/s12995-014-0042-5

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