Article
Investigation of tRNA(Leu/Lys) and ATPase 6 genes mutations in Huntington's disease.
Cellular and molecular neurobiology - 1 Nov 2008
Kasraie Sadaf, Houshmand Massoud, Banoei Mohammad Mehdi, Ahari Solmaz Etemad, Panahi Mehdi Shafa Shariat, Shariati Parvin, Bahar Mohammad, Moin Mostafa
Abstract excerpt
Huntington disease (HD) is a genetically dominant condition caused by expanded CAG repeats which code for glutamine in the HD gene product, huntingtin. Huntingtin is expressed in almost all tissues, so abnormalities outside the brain can also be expected. Involvement of nuclei and mitochondria in HD pathophysiology has been suggested. In fact mitochondrial dysfunction is reported in brains of patients suffering...
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