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Article

Acquisition, culture, and phenotyping of synovial fibroblasts.

Methods in molecular medicine - 1 Jan 2007

Rosengren Sanna, Boyle David L, Firestein Gary S

Abstract excerpt

The study of fibroblast-like synoviocytes (FLS) has yielded important insights into the pathogenic mechanisms of rheumatoid arthritis. FLS can be cultured from synovial tissue obtained at joint replacement surgery, synovectomy, or synovial biopsy. After collagenase digestion, adherent cells consist mainly of synovial fibroblasts and synovial macrophages. Proliferating FLS are enriched by repeated passage and...

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Identifiers

PMID: 17951672
DOI: 10.1007/978-1-59745-401-8_24

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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