Article
Characterization of fibroblasts responsible for cartilage destruction in arthritis.
Cytometry. Part A : the journal of the International Society for Analytical Cytology - 1 Apr 2008
Treese C, Mittag A, Lange F, Tarnok A, Loesche A, Emmrich F, Lehmann J, Sack U
Abstract excerpt
In the pathogenesis of rheumatoid arthritis (RA), synovial fibroblasts (SF) play a key role as they secrete distinct patterns of cytokines and express variable levels of costimulatory and adhesion molecules. The murine fibroblast cell line LS48 has been shown to be invasive in the cartilage destruction models in vivo and in vitro. The purpose of this study was to examine in detail the LS48 phenotype, to obtain a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.