Article
Absence of epidermal growth factor receptor mutations in cervical cancer.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Jan 2000
Arias-Pulido H, Joste N, Chavez A, Muller C Y, Dai D, Smith H O, Verschraegen C F
Abstract excerpt
Epidermal growth factor receptor (EGFR) is overexpressed in the majority of cervical cancers (CCs). Somatic mutations of EGFR have been associated with clinical response to tyrosine kinase inhibitors (TKIs) in lung cancer patients. This study was designed to establish the frequency of EGFR point mutations in patients diagnosed with high-grade squamous intraepithelial lesions (HSIL) and CC. Nine cell lines derived...
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