High epidermal growth factor receptor immunohistochemical expression in urothelial carcinoma of the bladder is not associated with EGFR mutations in exons 19 and 21: a study using formalin-fixed, paraffin-embedded archival tissues.

doi:10.1016/j.humpath.2011.11.016

Article

High epidermal growth factor receptor immunohistochemical expression in urothelial carcinoma of the bladder is not associated with EGFR mutations in exons 19 and 21: a study using formalin-fixed, paraffin-embedded archival tissues.

Human pathology - 1 Oct 2012

Chaux Alcides, Cohen Julie S, Schultz Luciana, Albadine Roula, Jadallah Sana, Murphy Kathleen M, Sharma Rajni, Schoenberg Mark P, Netto George J

Abstract excerpt

Epidermal growth factor receptor (EGFR) is a member of the erbB tyrosine kinase family reported to be overexpressed in a variety of solid malignancies. Mutations in exons 19 to 21 of the tyrosine kinase domain have been detected in a subset of these tumors and its presence associated with a better response to EGFR inhibitors. Several clinical trials are currently underway to evaluate the performance of such drugs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

High epidermal growth factor receptor immunohistochemical expression in urothelial carcinoma of the bladder is not associated with EGFR mutations in exons 19 and 21: a study using formalin-fixed, paraffin-embedded archival tissues.

Abstract excerpt

Topics

Related research