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Article

p53 mutations in deep tissues are more strongly associated with recurrence than mutation-positive mucosal margins.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2007

Huang Xiaohong, Pateromichelakis Stelios, Hills Allison, Sherriff Martyn, Lyons Andrew, Langdon John, Odell Edward, Morgan Peter, Harrison John, Partridge Max

Abstract excerpt

PURPOSE: Application of ultrasensitive diagnostics has shown that small numbers of p53 mutation-positive cells may signify the presence of residual tumor in histologically normal tissues after resection of squamous cell carcinomas arising in the head and neck area. To date, most studies in this area have focused on analysis of tissues at the mucosal aspect of the resection and highlighted the importance of...

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Identifiers

PMID: 17947474
DOI: 10.1158/1078-0432.CCR-07-1369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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