Article
Pre-malignant and malignant lymphoproliferations in an HCV-infected type II mixed cryoglobulinemic patient are sequential phases of an antigen-driven pathological process.
International journal of cancer - 15 Jul 2000
De Re V, De Vita S, Marzotto A, Gloghini A, Pivetta B, Gasparotto D, Cannizzaro R, Carbone A, Boiocchi M
Abstract excerpt
Type II mixed cryoglobulinemia (MC) is a systemic vasculitis characterized by the presence in the serum of a monoclonal cryoprecipitable IgM with rheumatoid factor (RF) activity. Hepatitis C virus (HCV) has been recognized as its major etiologic factor. Because MC frequently evolves into overt B-cell non-Hodgkin's lymphoma (NHL), chronic HCV infection is hypothesized to lead to both benign and malignant...
Topics
- Amino Acid Sequence
- Antibody Specificity
- Bone Marrow
- Cryoglobulinemia
- Genes, Immunoglobulin
- Hepacivirus
- Humans
- Immunoglobulin Variable Region
- Leukemia, Lymphocytic, Chronic, B-Cell
- Liver