Article
Phenotypic anchoring of global gene expression profiles induced by N-hydroxy-4-acetylaminobiphenyl and benzo[a]pyrene diol epoxide reveals correlations between expression profiles and mechanism of toxicity.
Chemical research in toxicology - 1 Apr 2005
Luo Wen, Fan Wenhong, Xie Hong, Jing Lichen, Ricicki Elaine, Vouros Paul, Zhao Lue Ping, Zarbl Helmut
Abstract excerpt
The goal of this study was to compare changes in gene expression induced by exposure to different carcinogens and to anchor these changes to the induced levels of toxicity and mutagenesis. The human TK6 lymphoblastoid cell line was used as an in vitro model system, and reactive metabolites of two...
Topics
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- Aminobiphenyl Compounds
- Carcinogens
- Cell Line
- Gene Expression Profiling
- Humans
- Mutagens
- Mutation
- Oligonucleotide Array Sequence Analysis
- Phenotype
- Regression Analysis